Author  
Place of duty  
Title   뇌종양 환자에서의 면역능력 평가 ( Evaluation of Immunocompetence in the Patients with the Brain Tumor )
Publicationinfo   1992 Jan; 024(01): 56-64.
Key_word   Immunocompetence, Brain tumor, CD,/CD, ratio, Mitogenic lectin, NK cell activity
Full-Text  
Abstract   To investigate the cell-mediated immune response to brain tumors, we obtained peripheral blood mononuclear cells from 51 patients with brain tumors, including 32 benign tumors and 19 malignant tumors. Additional samples from 20 normal people were studied for controL Three pa- rameters, CD4/CD8 ratio, proliferation response to mitogenic lectin in vitra and NK cell activity, were applied to evaluate the immunocompetence. The immunocompetence prior to surgery in the patients with brain tumors was reduced to 67 to 83 percent of the normal controL The immunocompetence after surgery was rather increased in 40 to 46 percent of patients with brain tumors, most of whom have the benign tumors. The immunocompetence after radiation therapy was reduced in 75 percent of the patients with brain tumors. In summary, the patients with brain tumors have the impaired cellular immune response and the degree of impairment may estimate prognosis and facilitate the design of the treatment reaimens for individual patients.
저 자   조경기(Kyung Gi Cho),김미정(Mi Jung Kim)